Spontaneous Regression Cancer and the Immune System by Donald H. MacAdam of MBVax Bioscience is an introduction to the spontaneous regression, treatments and causes of cancer including surgery, chemotherapy, radiation therapy, genetics, infection, the placebo effect and cancer immunology. Written for a general audience but referenced to more than 400 original sources. Click here for a PDF download [A1] of Chapter Two “Coley.”

Healing Heat by Heinz-Uwe Hobohm, a professor at the University of Applied Science in Giessen, Germany, and authority on innate immunology and the work of Dr. William Coley.

A Commotion in the Blood by Stephen S. Hall, a prominent science writer, is an examination of the development of immunology including an account of the life and work of Dr. William Coley.

Coley’s Toxins the Sum of Our Hope by prominent journalist and cancer advocate Ralph W. Moss, PhD, is an account of Coley’s life and his legacy. Available from the Cancer Decisions web site:


Dr William Coley and tumour regression: a place in history or in the future. Hoption Cann SA, van Netten JP, van Netten C. Postgraduate Med J 2003;79:672-680. Click here to download PDF [A2]

Spontaneous regression: a hidden treasure buried in time. Hoption Cann SA, van Netten JP, van Netten C, Glover DW. Med Hypotheses 2002;58:115-119. Click here to download PDF [A3]

Spontaneous regression of pancreatic cancer. Hoption Cann SA, Gunn H, van Netten JP, van Netten C. Case Rep Clin Prac Rev 2004;5:293-296. Click here to download PDF [A4]

Stromal regulation of cancer growth: a balancing act in surgery. van Netten JP, Hoption Cann SA, Fletcher CL. Int J Surgery 2009;7:88-90. Click here to download PDF [A5]

Pathogen-associated molecular pattern in cancer immunotherapy. Hobohm U, Stanford JL, Grange JM. Crit Rev Immunology 2008;28(2):95-107. Click here to download PDF [A6]

Fever therapy revisited. Hobohm U. British Journal of Cancer 2005;92:421-425. Click here to download PDF [A7]

Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley’s legacy revisited. Decker WK, Safdar A. Cytokine Growth Factor Rev 2009. Click here to download PDF [A8]

Bacterial anti-cancer vaccines: a science frozen in time. Microbiologist 2007;8(4):29-33. Click here to download PDF [A9]

The use of Coley’s mixed toxins in the treatment of chronic arthritis. Thomas Klein. Trans Am Climatolog Clin Assoc. 1923;39:67–73. Click here to download PDF [A10]

Matzinger P. The danger model: a renewed sense of self. Science. 2002 Apr 12;296(5566):301-5. Available at universities and larger public libraries.
Link to Abstract:

Additional reference materials. This link courtesy of Heinz-Uwe Hobohm, professor for bioinformatics, University of Applied Sciences, Giessen, Germany.

Audio and video

Link to National Public Radio interview with Uwe Hobohm, PhD, and Polly Matzinger, PhD, broadcast on December 12, 2009, “Coley’s Toxin, Cancer & Immunology.”

“Cancer Survivors USA a road trip and an open letter to Senator Tom Harkin” by Gar and Christeene Hildenbrand includes interviews with eight cancer patients who have received Coley Fluid therapy. The eight interviews are posted on YouTube.

NPR’s “The People’s Pharmacy” interview with Don MacAdam, originally aired August 14, 2010, program number 780, Cancer and the Immune System.

Direct link to the extended interview